The following is a major list of the cast members on JESSIE.
- Debby Ryan as Jessie Prescott
- Peyton List as Emma Ross
- Cameron Boyce as Luke Ross
- Karan Brar as Ravi Ross
- Skai Jackson as Zuri Ross
- Kevin Chamberlin as Bertram
- Chris Galya as Tony
- Chip Esten as Morgan Ross
- Christina Moore as Christina Ross
- Frank as Mr. Kipling
- Carolyn Hennesy as Mrs. Chesterfield
- Jennifer Veal as Agatha
To view the Cast gallery, click here.