- Jessie Prescott (Debby Ryan) is a fun-loving and friendly 19 year old Texan! She has big dreams for New York and is determined to see them all come true.
- Emma Ross (Peyton List) is the fashionista of the Ross family and a very motivated young girl. She strives to do her best with everything she does.
- Luke Ross (Cameron Boyce) is the hysterical troublemaker who loves causing mischief at the Ross home. He loves to dance and charm the ladies in his life.
- Ravi Ross (Karan Brar) is originally from India before being adopted by the Ross family. He is eager to learn American culture.
- Zuri Ross (Skai Jackson) is the most loving and imaginative girl you will ever meet! She loves her siblings but also enjoys causing a little mischief.
- Bertram Winkle (Kevin Chamberlin) is the sarcastic and often lazy butler. Underneath it all he has a soft spot for the Ross kids.